bigi 5a-d  (MultiTarget Pharmaceuticals)

Journal: Molecules

Article Title: Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

doi: 10.3390/molecules28010071

Figure Lengend Snippet: Design of multitarget-directed ligands BIGI 4a-d and BIGI 5a-d .

Article Snippet: Thus, the new multitarget-directed ligands BIGI 4a-d and BIGI 5a-d ( , ) were investigated for their calcium channels, ChE inhibition, antioxidant power, and Nrf2 activation.

Techniques:

Journal: Molecules

Article Title: Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

doi: 10.3390/molecules28010071

Figure Lengend Snippet: Synthesis of targeted multitarget-directed ligands BIGI 4a-d and BIGI 5a-d using one-pot Biginelli reaction.

Article Snippet: Thus, the new multitarget-directed ligands BIGI 4a-d and BIGI 5a-d ( , ) were investigated for their calcium channels, ChE inhibition, antioxidant power, and Nrf2 activation.

Techniques:

Journal: Molecules

Article Title: Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

doi: 10.3390/molecules28010071

Figure Lengend Snippet: Cholinesterases inhibition, calcium blockade percentages, and ORAC (TE) values for compounds BIGI 4a-d and BIGI 5a-d compared with reference compounds.

Article Snippet: Thus, the new multitarget-directed ligands BIGI 4a-d and BIGI 5a-d ( , ) were investigated for their calcium channels, ChE inhibition, antioxidant power, and Nrf2 activation.

Techniques: Inhibition

Journal: Molecules

Article Title: Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

doi: 10.3390/molecules28010071

Figure Lengend Snippet: Nrf2 transcriptional activation potencies of compounds BIGI 4b ( A ), BIGI 4d ( B ), BIGI 5b ( C ), and BIGI 5d ( D ) or reference compound TBHQ I ( E ). Data are means ± SEM of at least 3 different experiments. * p ≤ 0.05 and *** p ≤ 0.001 with respect to non-treated cells (control cells).

Article Snippet: Thus, the new multitarget-directed ligands BIGI 4a-d and BIGI 5a-d ( , ) were investigated for their calcium channels, ChE inhibition, antioxidant power, and Nrf2 activation.

Techniques: Activation Assay, Control

Journal: Molecules

Article Title: Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

doi: 10.3390/molecules28010071

Figure Lengend Snippet: Nrf2 induction potencies of compounds BIGI 4b , BIGI 4d , BIGI 5b , and BIGI 5d and reference compound TBHQ in Nrf2/ARE-luciferase reporter cells.

Article Snippet: Thus, the new multitarget-directed ligands BIGI 4a-d and BIGI 5a-d ( , ) were investigated for their calcium channels, ChE inhibition, antioxidant power, and Nrf2 activation.

Techniques:

Journal: Molecules

Article Title: Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

doi: 10.3390/molecules28010071

Figure Lengend Snippet: Physicochemical properties of the synthesized compounds calculated by Data Warrior.

Article Snippet: Thus, the new multitarget-directed ligands BIGI 4a-d and BIGI 5a-d ( , ) were investigated for their calcium channels, ChE inhibition, antioxidant power, and Nrf2 activation.

Techniques: Synthesized